Saracens have been Premiership champions in 2011, 2015, 2016 and 2018 and will begin the defence of their Premiership title with their longest trip of the season to Newcastle Falcons on 2 September.
Sarries, who have won three of the past four titles, will meet previous champions Exeter on the weekend of 21-23 December.
Newly-promoted Bristol kick off the campaign with a local derby at home to Bath on Friday, 31 August.
Exeter start the season at home to Leicester, while Wasps go to Worcester.
"To open the season against Bath - and to come up against Todd [Blackadder], a man I know and respect a huge amount - is really exciting and a major boost for our supporters," said Bristol head coach Pat Lam.
"We have no doubt they will fill Ashton Gate and create an incredible atmosphere."
Opening Premiership fixtures
◾Bristol v Bath (19:45 BST, Friday, 31 August)
◾Gloucester v Northampton (14:00 BST, Saturday, 1 September)
◾Harlequins v Sale Sharks (15:00 BST, Saturday, 1 September)
◾Worcester v Wasps (15:00 BST, Saturday, 1 September)
◾Exeter v Leicester (16:30 BST, Saturday, 1 September)
◾Newcastle v Saracens (15:00 BST, Sunday, 2 September)